Breathe in and Straighten Your Back: Hypoxia, Notch, and Scoliosis
نویسندگان
چکیده
In this issue of Cell, Sparrow et al. propose a new mechanism for sporadically occurring congenital scoliosis in which Notch signaling and hypoxia converge in the embryo on somite patterning via the segmentation clock. This interaction between hypoxia and a predisposed genetic background might underlie other birth defects with incomplete penetrance.
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ورودعنوان ژورنال:
- Cell
دوره 149 شماره
صفحات -
تاریخ انتشار 2012